Thyroid Hormone Receptor Interactor 6 (TRIP6)

OIP1; ZRP-1; Opa-interacting protein 1; Zyxin-related protein 1

SPN	P747
HGNC	12311
MGI	1343458
PubMed	16880273
UniProt	Q15654
Wiki	TRIP6

TRIP6 is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.Deconvolution microscopy demonstrated diffuse cytoplasmic colocalization of srfH and Trip6 in murine macrophages. Bacteria lacking SrfH were unable to stimulate TRIP6-dependent phagocyte migration in vitro or in vivo. Mice lacking Cd18 and infected with Salmonella did not show phagocyte migration, in spite of diminished bactericidal function.

Reference

"The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis."
Genomics 49:314-316(1998) [PubMed] [Europe PMC] [Abstract]

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Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor."
Mol. Endocrinol. 9:243-254(1995) [PubMed] [Europe PMC] [Abstract]

"A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters."
Genes Dev. 18:2518-2528(2004) [PubMed] [Europe PMC] [Abstract]

"TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor."
J. Biol. Chem. 279:10459-10468(2004) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins."
FEBS Lett. 579:5061-5068(2005) [PubMed] [Europe PMC] [Abstract]

"c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration."
Mol. Cell. Biol. 25:5859-5868(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase."
Cell. Signal. 18:1702-1712(2006) [PubMed] [Europe PMC] [Abstract]

"Supervillin modulation of focal adhesions involving TRIP6/ZRP-1."
J. Cell Biol. 174:447-458(2006) [PubMed] [Europe PMC] [Abstract]

"Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells."
Proc. Natl. Acad. Sci. U.S.A. 103:17915-17920(2006) [PubMed] [Europe PMC] [Abstract]

"PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration."
J. Biol. Chem. 282:24381-24387(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness."
FASEB J. 23:916-928(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first and second LIM domain of thyroid receptor interacting protein 6 (TRIP6)."
Submitted (OCT-2006) to the PDB data bank