Transketolase Like Protein 1 (TKTL1)

TKR; TKT2; TK 2; Transketolase-related protein; Transketolase 2

SPN	P725
HGNC	11835
MGI	1933244
PubMed	15991799
RGD	1593490
UniProt	P51854
Wiki	TKTL1

Transketolase (TKT;) is a thiamine-dependent enzyme that links the pentose phosphate pathway with the glycolytic pathway. As part of a systematic search for differentially expressed genes, Coy et al. (1996) isolated a novel transketolase-related gene, TKTL1, which they called TKR. They isolated transcripts encoding tissue-specific protein isoforms. Comparison with known transketolases demonstrated a TKR-specific deletion mutating 1 thiamine-binding site.

Genomic sequencing of the TKR gene by Coy et al. (1996) revealed the presence of a pseudoexon, as well as the acquisition of a tissue-specific spliced exon, compared to the TKT gene, which maps to 3p14.3.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	P725Hu01	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	MP725Hu21	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	PP725Hu01	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Transketolase Like Protein 1 (TKTL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Transketolase Like Protein 1 (TKTL1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Transketolase Like Protein 1 (TKTL1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Transketolase Like Protein 1 (TKTL1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Transketolase Like Protein 1 (TKTL1)	CLIA assay for Antigen Detection

Reference

"Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes."
Genomics 32:309-316(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer."
Clin. Lab. 51:257-273(2005) [PubMed] [Europe PMC] [Abstract]

"Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted."
Br. J. Cancer 94:578-585(2006) [PubMed] [Europe PMC] [Abstract]

"Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer."
Oncol. Rep. 16:657-661(2006) [PubMed] [Europe PMC] [Abstract]