Toll Like Receptor Adaptor Molecule 2 (TICAM2)

TRAM; TIRAP3; TIRP; Toll/Interleukin-1 Receptor Domain-Containing; TIR domain-containing adapter molecule 2; Toll-like receptor adaptor Protein 3; TRIF-related adapter molecule

SPN	P722
HGNC	21354
MGI	3040056
PubMed	15618008
UniProt	Q86XR7
Wiki	TICAM2

TIRP is a Toll/interleukin-1 receptor (IL1R) (TIR) domain-containing adaptor protein involved in Toll receptor signaling.The predicted 235-amino acid protein, which is 70% identical to the mouse protein, has a central TIR domain that is most similar to that of TRIF. Northern blot analysis indicated that TIRP is expressed ubiquitously. Transcripts of 3.8, 3.6, and 2.0 kb were detected, and they were differentially expressed in tissues. TIRAP , and TRIF, but not with MYD88, TLR2, or TLR4. Among IRAKs, TIRP interacted with wildtype IRAK2 and IRAKM (IRAK3), both of which lack kinase activity, but it interacted only with kinase-inactive mutants of IRAK1 and IRAK4. Analysis of deletion mutants determined that the TIR domain of TIRP interacted specifically with the TRAF domain of TRAF6; TIRP did not interact with TRAF5.

Reference

"TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]

"TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta."
J. Biol. Chem. 278:49751-49762(2003) [PubMed] [Europe PMC] [Abstract]

"LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF."
J. Exp. Med. 198:1043-1055(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Exp. Med. 198:1451-1451(2003)

"Natural selection in the TLR-related genes in the course of primate evolution."
Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

"TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway."
Nat. Immunol. 10:579-586(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction."
Proc. Natl. Acad. Sci. U.S.A. 103:6299-6304(2006) [PubMed] [Europe PMC] [Abstract]

"Trif-related adapter molecule is phosphorylated by PKCepsilon during Toll-like receptor 4 signaling."
Proc. Natl. Acad. Sci. U.S.A. 103:9196-9201(2006) [PubMed] [Europe PMC] [Abstract]

"TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88."
PLoS ONE 7:E38423-E38423(2012) [PubMed] [Europe PMC] [Abstract]