Toll Like Receptor Adaptor Molecule 1 (TICAM1)

TRIF; PRVTIRB; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; Proline-rich, vinculin and TIR domain-containing protein B

SPN	P721
HGNC	18348
MGI	2147032
PubMed	22205631
UniProt	Q8IUC6
Wiki	Trif

TRIF is primarily active in the spleen and is often regulated when MyD88 is deficient in the liver, indicating organ-specific regulation of signaling pathways. Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response in the host after mutations occur within intermediates of the pathway. Three TRAF-binding motifs present in the amino terminal region of TRIF are necessary for association with TRAF6. Destruction of these motifs reduced the activation of NF-κβ, a transcription factor that is also activated by the carboxy-terminal domain of TRIF in the upregulation of cytokines and co-stimulatory immune molecules. This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif.

Reference

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J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]

"TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."
Nat. Immunol. 4:161-167(2003) [PubMed] [Europe PMC] [Abstract]

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Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

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Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling."
J. Biol. Chem. 278:24526-24532(2003) [PubMed] [Europe PMC] [Abstract]

"Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling."
J. Immunol. 171:4304-4310(2003) [PubMed] [Europe PMC] [Abstract]

"PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis."
FEBS Lett. 570:97-101(2004) [PubMed] [Europe PMC] [Abstract]

"Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways."
J. Biol. Chem. 279:15652-15661(2004) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 101:3533-3538(2004) [PubMed] [Europe PMC] [Abstract]

"NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation."
J. Immunol. 174:27-30(2005) [PubMed] [Europe PMC] [Abstract]

"The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling."
Nat. Immunol. 7:1074-1081(2006) [PubMed] [Europe PMC] [Abstract]

"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling."
Nat. Rev. Immunol. 7:353-364(2007) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"TRIM38 negatively regulates TLR3-mediated IFN-beta signaling by targeting TRIF for degradation."
PLoS ONE 7:E46825-E46825(2012) [PubMed] [Europe PMC] [Abstract]

"The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins."
Acta Crystallogr. D 69:2420-2430(2013) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency."
J. Clin. Invest. 121:4889-4902(2011) [PubMed] [Europe PMC] [Abstract]