Thimet Oligopeptidase 1 (THOP1)

EP24.15; MEPD_HUMAN; MP78; Endopeptidase 24.15

SPN	P716
HGNC	11793
MGI	1354165
PubMed	9790774
RGD	68330
UniProt	P52888
Wiki	THOP1

Proteases involved in the amyloidogenic processing of amyloid precursor protein (APP) represent likely candidates for the site of mutation in a form of familial Alzheimer disease (AD2). Formation of toxic amyloid in the brain parenchyma and cerebral vasculature in Alzheimer disease requires the proteolytic release of the 39- to 43-amino acid amyloid beta peptide from its precursor, APP. Sequence comparison revealed that this enzyme, THOP1, has high homology to the previously described rat metalloendopeptidase 24.15 (EC 3.4.24.15). The beta-secretase-like activity of the human enzyme in vitro in combination with its localization in neurons and its co-localization with APP in transport vesicles purified from rabbit optic nerve rendered this enzyme an interesting candidate for amyloidogenic processing of APP.

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