Thymine DNA Glycosylase (TDG)

G/T Mismatch-Specific Thymine DNA Glycosylase; Thymine-DNA glycosylase

SPN	P690
HGNC	11700
MGI	108247
PubMed	21862836
RGD	620959
UniProt	Q13569
Wiki	TDG

Thymine-DNA Glycosylase(TDG) belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.These cDNAs encode a 410-amino acid, 46-kD polypeptide.

Reference

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"Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair."
Cell 146:67-79(2011) [PubMed] [Europe PMC] [Abstract]

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Nature 435:979-982(2005) [PubMed] [Europe PMC] [Abstract]

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"Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition."
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Nat. Chem. Biol. 8:328-330(2012) [PubMed] [Europe PMC] [Abstract]

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"Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA."
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