Synaptopodin 2 (SYNPO2)

Myopodin; Genethonin-2

SPN	P655
HGNC	17732
MGI	2153070
PubMed	23434281
RGD	1564779
UniProt	Q9UMS6
Wiki	SYNPO2

Synaptopodin-2 is a protein encoded by the SYNPO2 gene. An analysis of the primary structure of the actin-binding protein fesselin revealed it to be the avian homologue of mammalian synaptopodin 2

Both avian fesselin and mammalian synaptopodin 2 bound to Ca(2+)-calmodulin, alpha-actinin and smooth-muscle myosin. In addition, both proteins stimulated the polymerization of actin in a Ca(2+)-calmodulin-dependent manner. Synaptopodin 2 has never before been shown to polymerize actin in the absence of alpha-actinin, to polymerize actin in a Ca(2+)-calmodulin-dependent manner, or to bind to Ca(2+)-calmodulin or myosin. These properties are consistent with the proposed function of synaptopodin 2 in organizing the cytoskeleton.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Hu01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Hu01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Hu01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Hu01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Hu01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Mu01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Mu01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Mu01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Mu01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Mu01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Ra01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Ra01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Ra01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Ra01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Ra01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Ca01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Ca01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Ca01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Ca01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Ca01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Po01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Po01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Po01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Po01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Po01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Bo01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Bo01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Bo01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Bo01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Bo01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Rb01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Rb01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Rb01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Rb01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Rb01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP655Mo01	Recombinant Synaptopodin 2 (SYNPO2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP655Mo01	Monoclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IP.
Antibodies	PAP655Mo01	Polyclonal Antibody to Synaptopodin 2 (SYNPO2)	WB; IHC; ICC; IF.
Assay Kits	CLP655Mo01	CLIA Kit for Synaptopodin 2 (SYNPO2)	CLIA assay for Antigen Detection
Assay Kits	ELP655Mo01	ELISA Kit for Synaptopodin 2 (SYNPO2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells."
Biochem. Biophys. Res. Commun. 370:269-273(2008) [PubMed] [Europe PMC] [Abstract]

"Myopodin isoforms alter the chemokinetic response of PC3 cells in response to different migration stimuli via differential effects on Rho-ROCK signaling pathways."
Carcinogenesis 33:2100-2107(2012) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Differentiation and stress-dependent nuclear-cytoplasmic redistribution of myopodin, a novel actin bundling protein."
J. Cell Biol. 155:393-404(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of altered gene expression in skeletal muscles from Duchenne muscular dystrophy patients."
Neuromuscul. Disord. 11:269-277(2001) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]