Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2)
IPCA1; PCANAP1; PUMPCn; STAMP1; STMP; Prostate Cancer Associated Protein 1; Protein up-regulated in metastatic prostate cancer; SixTransMembrane protein of prostate 1
STEAP2 is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
The deduced 490-amino acid protein contains a 6-transmembrane domain in its C-terminal half. STEAP2 shares 43% identity with the mouse Tiarp protein and 51% identity with the rat Hyde protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Hu01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Hu01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Hu01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Hu01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Hu01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Mu01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Mu01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Mu01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Mu01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Mu01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Ra01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Ra01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Ra01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Ra01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Ra01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Ca01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Ca01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Ca01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Ca01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Ca01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Po01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Po01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Po01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Po01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Po01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Bo01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Bo01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Bo01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Bo01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Bo01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Rb01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Rb01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Rb01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Rb01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Rb01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP621Mo01 | Recombinant Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP621Mo01 | Monoclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IP. |
| PAP621Mo01 | Polyclonal Antibody to Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP621Mo01 | CLIA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | CLIA assay for Antigen Detection |
| ELP621Mo01 | ELISA Kit for Six Transmembrane Epithelial Antigen Of The Prostate 2 (STEAP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and characterization of STAMP1, a highly prostate specific six-trans-membrane protein that is overexpressed in prostate cancer."
J. Biol. Chem. 277:36689-36696(2002) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate."
Lab. Invest. 82:1573-1582(2002) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
"The Steap proteins are metalloreductases."
Blood 108:1388-1394(2006) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]