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STAM Binding Protein (STAMBP)

AMSH; Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase

Signal-transducing adaptor molecule (STAM) acts downstream of interleukin-2 (IL2)-induced signaling through JAK3. It also interacts with JAK2 after granulocyte-macrophage colony-stimulating factor (GMCSF) stimulation. STAM contains an SH3 domain that is required for induction of MYC and cell growth.
STAMBP binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.The deduced 424-amino acid protein contains 2 potential SH3-binding domains (PxxP motifs), a JAB1 subdomain homologous (JSH) region, and a putative bipartite nuclear localization signal.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
PP620Hu01 Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
PP620Mu01 Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant STAM Binding Protein (STAMBP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native STAM Binding Protein (STAMBP) Bioactivity
Antibodies NONE Monoclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to STAM Binding Protein (STAMBP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to STAM Binding Protein (STAMBP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for STAM Binding Protein (STAMBP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for STAM Binding Protein (STAMBP) CLIA assay for Antigen Detection

Reference

"Possible involvement of a novel STAM-associated molecule 'AMSH' in intracellular signal transduction mediated by cytokines."
J. Biol. Chem. 274:19129-19135(1999) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site."
BMC Genomics 10:518-518(2009) [PubMed] [Europe PMC] [Abstract]

"Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads."
EMBO J. 20:4132-4142(2001) [PubMed] [Europe PMC] [Abstract]

"MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function."
BMC Biochem. 3:28-28(2002) [PubMed] [Europe PMC] [Abstract]

"AMSH is an endosome-associated ubiquitin isopeptidase."
J. Cell Biol. 166:487-492(2004) [PubMed] [Europe PMC] [Abstract]

"An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."
Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]

"Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding."
Proc. Natl. Acad. Sci. U.S.A. 103:19140-19145(2006) [PubMed] [Europe PMC] [Abstract]

"Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation."
J. Biol. Chem. 282:9805-9812(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome."
Nat. Genet. 45:556-562(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]