Serine Peptidase Inhibitor Kunitz Type 2 (SPINT2)

HAI2; Kop; PB; Placental Bikunin; Hepatocyte growth factor activator inhibitor type 2

SPN	P601
HGNC	11247
MGI	1338031
PubMed	19047176
RGD	SPINT2
UniProt	O43291
Wiki	SPINT2

SPINT2 encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.SPINT2 protein is structurally similar to SPINT1 and contains an N-terminal putative signal peptide sequence, a hydrophobic, membrane associated C-terminal region, and a central region that encodes the processed, cleaved protein. SPINT2 has 2 potential N-glycosylation sites, but a different N-linked sugar chain from that of SPINT1. Two regions show extensive similarity to the Kunitz-type sequence of serine protease inhibitors

Reference

"Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor."
J. Biol. Chem. 272:27558-27564(1997) [PubMed] [Europe PMC] [Abstract]

"Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains."
J. Biol. Chem. 272:12202-12208(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer."
Biochim. Biophys. Acta 1395:88-95(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea."
Am. J. Hum. Genet. 84:188-196(2009) [PubMed] [Europe PMC] [Abstract]