Serine Peptidase Inhibitor Kazal Type 1 (SPINK1)

PCTT; PSTI; TATI; Tumor-Associated Trypsin Inhibitor; Pancreatic secretory trypsin inhibitor; Tumor-associated trypsin inhibitor

SPN	P600
HGNC	11244
MGI	106202
PubMed	21610753
RGD	3749
UniProt	P00995
Wiki	SPINK1

SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.The 79-amino acid sequence contains a 23-amino acid signal peptide followed directly by the 56-amino acid mature secreted form.

Tumor-associated trypsin inhibitor (TATI) is identical to PSTI. TATI is a 6-kD peptide that is synthesized by several tumors and cell lines. It was initially detected in urine of patients with ovarian cancer .This peptide is also produced by the mucosa of the gastrointestinal tract where it may protect the mucosal cells from proteolytic breakdown.

Reference

"Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene."
Biochem. Biophys. Res. Commun. 149:635-641(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA."
Biochem. Biophys. Res. Commun. 132:605-612(1985) [PubMed] [Europe PMC] [Abstract]

"Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues."
FEBS Lett. 225:113-119(1987) [PubMed] [Europe PMC] [Abstract]

"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis."
Nat. Genet. 25:213-216(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein."
Arch. Biochem. Biophys. 179:189-199(1977) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer."
J. Biol. Chem. 257:13713-13716(1982) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)."
J. Mol. Biol. 225:1095-1103(1992) [PubMed] [Europe PMC] [Abstract]

"Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy."
J. Mol. Biol. 229:695-706(1993) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis."
J. Med. Genet. 37:67-69(2000) [PubMed] [Europe PMC] [Abstract]

"SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent."
Am. J. Hum. Genet. 71:964-968(2002) [PubMed] [Europe PMC] [Abstract]

"Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis."
J. Med. Genet. 39:347-351(2002) [PubMed] [Europe PMC] [Abstract]

"Gene symbol: Spink1-Omim 167790. Disease: hereditary pancreatitis."
Hum. Genet. 113:369-369(2003) [PubMed] [Europe PMC] [Abstract]