Laminin Beta 1 (LAMb1)

LAM-B1; CLM; Cutis Laxa With Marfanoid Phenotype

SPN	P593
HGNC	6486
MGI	96743
PubMed	23472759
RGD	1306311
UniProt	P07942
Wiki	LAMB1

Laminin subunit beta-1 is the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor.

A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Reference

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"Human laminin B1 chain. A multidomain protein with gene (LAMB1) locus in the q22 region of chromosome 7."
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Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities."
Am. J. Hum. Genet. 92:468-474(2013) [PubMed] [Europe PMC] [Abstract]

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