Suppressors Of Cytokine Signaling 1 (SOCS1)

CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3; JAK-binding protein; STAT-induced STAT inhibitor 1; Tec-interacting protein 3

SPN	P584
HGNC	19383
MGI	1354910
PubMed	21893603
RGD	69272
UniProt	O15524
Wiki	SOCS1

SOCS1 orthologs have been identified in several mammals for which complete genome data are available.This SOCS1 encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Reference

"Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3."
Biochem. Biophys. Res. Commun. 237:79-83(1997) [PubMed] [Europe PMC] [Abstract]

"SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase."
J. Biol. Chem. 272:27178-27182(1997) [PubMed] [Europe PMC] [Abstract]

"A family of cytokine-inducible inhibitors of signaling."
Nature 387:917-921(1997) [PubMed] [Europe PMC] [Abstract]

"Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively."
Genomics 61:108-111(1999) [PubMed] [Europe PMC] [Abstract]

"A new protein containing an SH2 domain that inhibits JAK kinases."
Nature 387:921-924(1997) [PubMed] [Europe PMC] [Abstract]

"Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor."
J. Biol. Chem. 273:24095-24101(1998) [PubMed] [Europe PMC] [Abstract]

"The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2."
J. Biol. Chem. 276:12530-12538(2001) [PubMed] [Europe PMC] [Abstract]

"Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation."
Mol. Cell. Biol. 21:3547-3557(2001) [PubMed] [Europe PMC] [Abstract]

"SOCS proteins: negative regulators of cytokine signaling."
Stem Cells 19:378-387(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]

"Cytokine signaling in the brain: putting a SOCS in it?"
J. Neurosci. Res. 67:423-427(2002) [PubMed] [Europe PMC] [Abstract]

"Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling."
J. Cell Sci. 119:380-387(2006) [PubMed] [Europe PMC] [Abstract]