Semenogelin I (SEMG1)

SEMG; SGI; CT103; Semen Coagulating Protein; Cancer/Testis Antigen 103; Seminal basic protein

SPN	P557
HGNC	10742
MGI	1858275
PubMed	2912989
RGD	3790
UniProt	P04279
Wiki	SEMG1

Semenogelin I is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.An open reading frame of 1,386 nucleotides encoded a signal peptide and a mature protein of 439 amino acid residues, in which residues 85 to 136 were identical with a previously characterized semenogelin fragment. An abundant seminal vesicular mRNA transcript of 1.8 kb codes for semenogelin.

Reference

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"Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20."
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"Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen."
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"Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein."
Cell. Mol. Life Sci. 55:944-960(1999) [PubMed] [Europe PMC] [Abstract]

"Association of eppin with semenogelin on human spermatozoa."
Biol. Reprod. 72:1064-1070(2005) [PubMed] [Europe PMC] [Abstract]

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Biol. Reprod. 77:476-484(2007) [PubMed] [Europe PMC] [Abstract]

"Analysis of recombinant human semenogelin as an inhibitor of human sperm motility."
Biol. Reprod. 82:489-496(2010) [PubMed] [Europe PMC] [Abstract]