Scavenger Receptor Class B Member 1 (SCARB1)

CD36L1; SRB1; CLA1, SR-BI; Collagen Type I Receptor Thrombospondin Receptor-Like 1; CD36 and LIMPII analogous 1

SPN	P548
HGNC	1664
MGI	893578
PubMed	23023567
RGD	2302
UniProt	Q8WTV0
Wiki	SCARB1

Using degenerate PCR, Calvo and Vega (1993) isolated a novel sequence closely related to both the CD36 thrombospondin/collagen receptor and to lysosomal integral membrane protein II (LIMPII). This novel gene was termed CLA1 for 'CD36 and LIMPII analogous-1.' Calvo and Vega (1993) isolated 2 alternatively spliced CLA1 cDNAs predicting proteins of 409 and 509 amino acids from a human placenta cDNA library. Calvo and Vega (1993) stated that the full-length CLA1 sequence predicts a glycoprotein having 2 transmembrane domains, 2 short cytoplasmic tails, and a large extracellular loop. They used immunofluorescence to show that the protein is found on the plasma membrane. Northern blot analysis revealed a 2.9-kb mRNA in several cell lines.

Reference

"Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family."
J. Biol. Chem. 268:18929-18935(1993) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus."
EMBO J. 21:5017-5025(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular Sertoli cells."
J. Biol. Chem. 277:27559-27566(2002) [PubMed] [Europe PMC] [Abstract]

"Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor."
J. Biol. Chem. 278:41624-41630(2003) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Biological, clinical and population relevance of 95 loci for blood lipids."
Nature 466:707-713(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Polymorphisms at the SRBI locus are associated with lipoprotein levels in subjects with heterozygous familial hypercholesterolemia."
Clin. Genet. 63:53-58(2003) [PubMed] [Europe PMC] [Abstract]

"Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]

"Genetic variant of the scavenger receptor BI in humans."
N. Engl. J. Med. 364:136-145(2011) [PubMed] [Europe PMC] [Abstract]