Protamine 2 (PRM2)

CT94.2; Cancer/Testis Antigen Family 94,Member 2; Sperm histone P2; Sperm protamine P2

SPN	P435
HGNC	9448
MGI	97766
PubMed	24146628
RGD	3409
UniProt	P04554

Presumably PRM2 is located on human chromosome 16, close to PRM1: in the mouse the corresponding 2 loci are closely linked, and in the Chinese hamster, probes specific for the 2 protamines hybridize to the same restriction fragments after digestion of hamster genomic DNA with any of 5 different restriction endonucleases (Reeves et al., 1987, 1989). The tight linkage may be of functional significance since PRM1 and PRM2 are among the limited number of genes known to be expressed postmeiotically in haploid cells.

In mouse, only one P2 protamine has been detected, whereas in man, the P2 protamine family is represented by 3 protamines, HP2, HP3 and HP4, whose amino acid sequences are identical except at their amino terminal ends .

Reference

"Sequence of human protamine 2 cDNA."
Nucleic Acids Res. 16:7733-7733(1988) [PubMed] [Europe PMC] [Abstract]

"Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."
Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]

"Characterization of a human locus in transition."
J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]

"Rapid evolution of male reproductive genes in the descent of man."
Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of nuclear basic protein HPI1, a putative precursor of human sperm protamines HP2 and HP3."
Eur. J. Biochem. 191:449-451(1990) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the human intermediate basic protein 2 (HPI2) from sperm nuclei. Structural relationship with protamine P2."
Eur. J. Biochem. 214:445-450(1993) [PubMed] [Europe PMC] [Abstract]

"Comparison of the amino acid sequences of human protamines HP2 and HP3 and of intermediate basic nuclear proteins HPS1 and HPS2. Structural evidence that HPS1 and HPS2 are pro-protamines."
J. Biol. Chem. 263:11059-11063(1988) [PubMed] [Europe PMC] [Abstract]

"Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."
Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]

"Human sperm protamines. Amino-acid sequences of two forms of protamine P2."
Eur. J. Biochem. 156:5-8(1986) [PubMed] [Europe PMC] [Abstract]

"Molecular structure of human protamine P4 (HP4), a minor basic protein of human sperm nuclei."
Eur. J. Biochem. 200:387-392(1991) [PubMed] [Europe PMC] [Abstract]