Preferentially Expressed Antigen In Melanoma (PRAME)
MAPE; OIP4; CT130; Cancer/Testis Antigen 130; Opa-interacting protein 4; Melanoma antigen preferentially expressed in tumors
PRAME is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. The deduced 509-amino acid PRAME protein contains no signal sequence. Northern blot analysis detected 2.2- and 3.0-kb PRAME transcripts in tumor cell lines but not in normal tissue except testis. RT-PCR analysis detected very low expression of PRAME in ovary and adrenals. Functional analysis showed that PRAME-specific CTLs can lyse MEL.B but not MEL.A cells due to inhibition mediated by the interaction of a p58.2 molecule (KIR2DL2) on the CTLs with HLA-Cw7 on the melanoma target cell.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Hu01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Hu01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Hu01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Hu01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Hu01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Mu01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Mu01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Mu01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Mu01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Mu01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Ra01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Ra01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Ra01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Ra01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Ra01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Ca01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Ca01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Ca01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Ca01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Ca01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Po01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Po01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Po01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Po01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Po01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Bo01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Bo01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Bo01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Bo01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Bo01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Rb01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Rb01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Rb01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Rb01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Rb01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP419Mo01 | Recombinant Preferentially Expressed Antigen In Melanoma (PRAME) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP419Mo01 | Monoclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IP. |
| PAP419Mo01 | Polyclonal Antibody to Preferentially Expressed Antigen In Melanoma (PRAME) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP419Mo01 | CLIA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | CLIA assay for Antigen Detection |
| ELP419Mo01 | ELISA Kit for Preferentially Expressed Antigen In Melanoma (PRAME) | Enzyme-linked immunosorbent assay for Antigen Detection |
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