Paraneoplastic Antigen MA2 (PNMA2)

RGAG2; 40 kDa neuronal protein; Onconeuronal antigen Ma2; Paraneoplastic neuronal antigen MM2

SPN	P392
HGNC	9159
MGI	2444129
PubMed	22173169
RGD	1307266
UniProt	Q9UL42
Wiki	PNMA2

In patients with cancer, symptoms of limbic and brainstem dysfunction may result from a paraneoplastic disorder. Paraneoplastic limbic or brainstem encephalitis occurs more frequently with testicular cancer than with most other cancers.

By immunohistochemical and immunoblotting techniques, Voltz et al. (1999) detected antibodies in serum and cerebrospinal fluid against a 40-kD neuronal protein in 10 of 13 patients with testicular cancer and paraneoplastic limbic or brainstem encephalitis, or both. They designated the protein MA2, and found that it was selectively expressed by normal brain tissue and by the testicular tumors of the patients. MA2 shares homology with MA1, a 'brain-testis-cancer' gene related to other neoplastic syndromes and tumors.

Reference

"A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer."
N. Engl. J. Med. 340:1788-1795(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular and clinical diversity in paraneoplastic immunity to Ma proteins."
Ann. Neurol. 50:339-348(2001) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]