Plexin B1 (PLXNB1)

PLXN5; SEP; Semaphorin receptor SEP

SPN	P377
HGNC	9103
MGI	2154238
PubMed	22019888
RGD	1310564
UniProt	O43157
Wiki	PLXNB1

The cDNA sequence (FB7) was isolated by serendipity from a human fetal brain cDNA library. The SEP gene was expressed at highest levels in fetal kidney.

PLXNB1 is a receptor for the transmembrane semaphorin SEMA4D, also called CD100. Binding of SEMA4D to PLXNB1 stimulated tyrosine kinase activity of MET, resulting in tyrosine phosphorylation of both receptors. This effect was not found in cells lacking MET expression.This activity required the interaction of plexin B1 with RND1 , a small GTP-binding protein of the Rho family. Downregulation of RRAS activity by the plexin B1/RND1 complex was essential for the SEMA4D-induced growth cone collapse in hippocampal neurons.

Reference

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DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]

"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Cell 104:321-321(2001)

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner."
Proc. Natl. Acad. Sci. U.S.A. 97:12457-12462(2000) [PubMed] [Europe PMC] [Abstract]

"The semaphorin 4D receptor controls invasive growth by coupling with Met."
Nat. Cell Biol. 4:720-724(2002) [PubMed] [Europe PMC] [Abstract]

"The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG."
Proc. Natl. Acad. Sci. U.S.A. 99:12085-12090(2002) [PubMed] [Europe PMC] [Abstract]

"Functional regulation of semaphorin receptors by proprotein convertases."
J. Biol. Chem. 278:10094-10101(2003) [PubMed] [Europe PMC] [Abstract]

"Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells."
J. Biol. Chem. 278:25671-25677(2003) [PubMed] [Europe PMC] [Abstract]

"Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2."
J. Cell Biol. 165:869-880(2004) [PubMed] [Europe PMC] [Abstract]

"Interplay between scatter factor receptors and B plexins controls invasive growth."
Oncogene 23:5131-5137(2004) [PubMed] [Europe PMC] [Abstract]

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain."
J. Biol. Chem. 282:37215-37224(2007) [PubMed] [Europe PMC] [Abstract]

"Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor."
Protein Sci. 17:1003-1014(2008) [PubMed] [Europe PMC] [Abstract]

"Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain."
Structure 16:246-258(2008) [PubMed] [Europe PMC] [Abstract]

"Structure and function of the intracellular region of the plexin-B1 transmembrane receptor."
J. Biol. Chem. 284:35962-35972(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis of semaphorin-plexin signalling."
Nature 467:1118-1122(2010) [PubMed] [Europe PMC] [Abstract]

"A dual binding mode for RhoGTPases in plexin signalling."
PLoS Biol. 9:E1001134-E1001134(2011) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]