Plasmalemma Vesicle Associated Protein (PLVAP)

FELS; PV-1; PV1; gp68; Fenestrated-Endothelial Linked Structure Protein; Plasmalemma vesicle protein 1

SPN	P372
HGNC	13635
MGI	1890497
PubMed	23063469
RGD	619971
UniProt	Q9BX97
Wiki	PLVAP

PLVAP is a type II integral membrane protein with a short N-terminal cytoplasmic tail, a single-span transmembrane domain, and a large C-terminal extracellular domain consisting mostly of alpha helices. It also contains 2 coiled-coil domains predicted to contribute to dimer formation. The extracellular domain has 4 N-glycosylation sites, a proline-rich region, and regular spacing of cysteine residues. The deduced 439-amino acid mouse Plvap protein contains a consensus casein kinase II phosphorylation site that is not found in the human protein. Rat Plvap contains 2 casein kinase II phosphorylation sites. Northern blot analysis revealed a single PLVAP transcript of about 2.4 kb in pancreas, kidney, placenta, muscle, lung, heart, and liver. No signal was detected in brain or testis.

Reference

"cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes."
Genomics 72:304-313(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms."
Mol. Biol. Cell 15:3615-3630(2004) [PubMed] [Europe PMC] [Abstract]

"Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)."
J. Pathol. 206:466-475(2005) [PubMed] [Europe PMC] [Abstract]