Pleiomorphic Adenoma Gene Like Protein 1 (PLAGL1)

LOT1; ZAC; ZAC1; Zinc finger protein PLAGL1; Lost on transformation 1; Tumor suppressor ZAC

SPN	P364
HGNC	9046
MGI	1100874
PubMed	10655556
RGD	3014
UniProt	Q9UM63
Wiki	PLAGL1

PLAGL1 encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.The deduced 667-amino acid protein contains 7 C2H2 zinc fingers in its N-terminal half. Northern blot analysis of several mouse tissues detected highest Zac1 expression in pituitary.Rat and human LOT1 share 67.7% amino acid identity overall, with 85.5% identity in the N-terminal zinc finger region. Northern blot analysis detected multiple LOT1 transcripts in all human tissues examined, including spleen, thymus, prostate, testis, ovary, intestine, colon, and leukocytes. Highest expression was detected in ovary.

Reference

"Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors."
Oncogene 14:1973-1979(1997) [PubMed] [Europe PMC] [Abstract]

"Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]

"hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer."
Proc. Natl. Acad. Sci. U.S.A. 95:8835-8840(1998) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities."
Oncogene 20:1246-1253(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1."
Int. J. Biochem. Cell Biol. 40:1826-1834(2008) [PubMed] [Europe PMC] [Abstract]