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Polybromo 1 (PBRM1)

PB1; BAF180; BRG1-associated factor 180

The deduced 1,582-amino acid BAF180 protein, which is 90% identical to the chicken polybromo-1 protein, possesses 5 bromodomains, 2 bromo-adjacent homology (BAH) regions, and 1 high-mobility group (HMG) motif. BAF180 is also highly homologous to yeast Rsc1, Rsc2, and Rsc3, essential proteins that are required for cell cycle progression through mitosis.
Northern blot analysis revealed wide expression of 9.5- and 7.5-kb BAF180 transcripts. Immunofluorescence microscopy demonstrated that BAF180 was expressed in the nucleus during interphase but colocalized with cytoplasmic dynein at some kinetochores during prometaphase. The localization of BAF180 at kinetochores was not observed in metaphase, anaphase, or telophase.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Hu01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Hu01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Hu01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Hu01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Hu01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Mu01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Mu01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Mu01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Mu01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Mu01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Ra01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Ra01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Ra01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Ra01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Ra01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Ca01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Ca01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Ca01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Ca01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Ca01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Po01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Po01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Po01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Po01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Po01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Bo01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Bo01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Bo01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Bo01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Bo01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Rb01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Rb01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Rb01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Rb01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Rb01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP298Mo01 Recombinant Polybromo 1 (PBRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP298Mo01 Monoclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IP.
PAP298Mo01 Polyclonal Antibody to Polybromo 1 (PBRM1) WB; IHC; ICC; IF.
Assay Kits CLP298Mo01 CLIA Kit for Polybromo 1 (PBRM1) CLIA assay for Antigen Detection
ELP298Mo01 ELISA Kit for Polybromo 1 (PBRM1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Proc. Natl. Acad. Sci. U.S.A. 97:13015-13020(2000) [PubMed] [Europe PMC] [Abstract]

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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
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"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
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"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

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"PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes."
Genes Dev. 19:1662-1667(2005) [PubMed] [Europe PMC] [Abstract]

"Structural insights into selective histone H3 recognition by the human polybromo bromodomain 2."
Cell Res. 20:529-538(2010) [PubMed] [Europe PMC] [Abstract]

"Histone recognition and large-scale structural analysis of the human bromodomain family."
Cell 149:214-231(2012) [PubMed] [Europe PMC] [Abstract]