Palmdelphin (PALMD)

PALML; C1orf11; Paralemmin Like Protein

SPN	P272
HGNC	15846
MGI	2148896
PubMed	16323283
RGD	1305624
UniProt	Q9NP74

It has an N-terminal coiled-coil region that shares 45% amino acid identity with an N-terminal region in AKAP2 . Overall, PALML shares 36% amino acid identity with paralemmin (PALM). The shorter PALML variant encodes a deduced 471-amino acid protein that, compared with long isoform, lacks the N-terminal coiled-coil region and differs in the first 19 amino acids. Northern blot analysis detected a 2.4-kb PALML transcript enriched in testis, prostate, heart, and skeletal muscle. No expression was detected in brain and peripheral blood leukocytes, and alternative transcripts were detected in heart, liver, and skeletal muscle. Epitope-tagged PALML was expressed throughout the cytoplasm of transfected COS-7 cells and was excluded from the nucleus.

Reference

"The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative."
Biochem. Biophys. Res. Commun. 285:1369-1376(2001) [PubMed] [Europe PMC] [Abstract]

"PALML, a novel paralemmin-related gene mapping on human chromosome 1p21."
Gene 278:33-40(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]