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Neuropathy Target Esterase (NTE)

PNPLA6; Sws; Patatin-Like Phospholipase Domain Containing 6

Neuropathy Target Esterase deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. The deduced 1,327-amino acid protein contains 4 predicted transmembrane domains and multiple potential sites for N- and O-linked glycosylation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins P221Ra01 Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies MP221Ra21 Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
PP221Ra01 Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits KEP221Ra ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Neuropathy Target Esterase (NTE) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Neuropathy Target Esterase (NTE) Bioactivity
Antibodies NONE Monoclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Neuropathy Target Esterase (NTE) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Neuropathy Target Esterase (NTE) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Neuropathy Target Esterase (NTE) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Neuropathy Target Esterase (NTE) CLIA assay for Antigen Detection

Reference

"Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man."
Biochem. J. 332:1-4(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The pathogenesis of organophosphate polyneuropathy."
Crit. Rev. Toxicol. 21:465-487(1991) [PubMed] [Europe PMC] [Abstract]

"Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells."
J. Biol. Chem. 279:24024-24033(2004) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Neuropathy target esterase gene mutations cause motor neuron disease."
Am. J. Hum. Genet. 82:780-785(2008) [PubMed] [Europe PMC] [Abstract]

"PNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum."
Brain 137:69-77(2014) [PubMed] [Europe PMC] [Abstract]