Neuronal PAS Domain Protein 4 (NPAS4)

PASD10; NXF; Le-PAS; bHLHe79; Class E basic helix-loop-helix protein 79; HLH-PAS transcription factor NXF; PAS domain-containing protein 10

SPN	P211
HGNC	18983
MGI	2664186
PubMed	23029555
RGD	628866
UniProt	Q8IUM7

NXF is a member of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events.

The deduced 802-amino acid protein contains an N-terminal bHLH domain, followed by 2 PAS domains and a C-terminal activation domain. Northern blot analysis of several adult tissues detected robust expression only in brain, with faint expression in skeletal muscle and kidney. In developing mouse brain, expression of Nxf was only detectable beginning at embryonic day 17 and was higher in the 4-week postnatal brain. In situ hybridization of adult rat brain revealed punctate expression in the cerebral cortex and striatum, with prominent expression in the neuronal cell layers of the hippocampus.

Reference

"Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression."
Mol. Cell. Biol. 24:608-616(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]