Ninjurin 1 (NINJ1)

NIN1; Nerve Injury-Induced Protein-1

SPN	P195
HGNC	7824
MGI	1196617
PubMed	8780658
RGD	3179
UniProt	Q92982
Wiki	NINJ1

The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells. It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.

ninjurin is widely expressed in both adult and embryonic tissues, primarily those of epithelial origin. They used aggregation assays to demonstrate that ninjurin-mediated adhesion requires divalent cations and is an energy-dependent process. The critical domain for ninjurin-mediated homophilic adhesion was localized to an 11-residue region between pro26 and asn37 by mutagenesis and by employing synthetic oligopeptides as competitive inhibitors of ninjurin-mediated adhesion.

Reference

"Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth."
Neuron 17:353-361(1996) [PubMed] [Europe PMC] [Abstract]

"The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI)."
Genomics 47:58-63(1998) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule."
J. Biol. Chem. 272:21373-21380(1997) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]