C-Myc Binding Protein (MYCBP)

AMY-1; Associate Of Myc-1

SPN	P142
HGNC	7554
MGI	1891750
PubMed	20562918
UniProt	Q99417
Wiki	MYCBP

The MYCBP gene encodes a protein that binds to the N-terminal region of MYC and stimulates the activation of E box-dependent transcription by MYC.The MYC protooncogene appears to play key roles in cell proliferation, differentiation, transformation, and apoptosis. A variety of functions of the MYC gene product are attributable to protein-protein interactions with various cellular factors. AMY1 was found to bind in vitro and in vivo to the regulatory subunit II-binding region of AKAP1 and S-AKAP84, a splicing variant of AKAP149 expressed in the testis. AMY1 was expressed postmeiotically in the testis, as was also S-AKAP84. AMY1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggested that AMY1 plays a role in spermatogenesis.

Reference

"AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC."
Genes Cells 3:549-565(1998) [PubMed] [Europe PMC] [Abstract]

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"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase."
J. Biol. Chem. 276:36647-36651(2001) [PubMed] [Europe PMC] [Abstract]

"AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis."
Biochim. Biophys. Acta 1577:126-132(2002) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of c-myc-1 binding protein domain from Homo sapiens."
Submitted (APR-2008) to the PDB data bank