V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (MAF)

c-MAF; Proto-oncogene c-Maf; Transcription factor Maf

SPN	P139
HGNC	6776
MGI	96909
PubMed	2554284
RGD	3034
UniProt	O75444
Wiki	MAF

MAF is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor.

This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.Members of the MAF family appear to play important roles in the regulation of differentiation.

Reference

"Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma."
Blood 91:4457-4463(1998) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction."
Oncogene 21:5301-5312(2002) [PubMed] [Europe PMC] [Abstract]

"Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma."
Cancer Cell 5:191-199(2004) [PubMed] [Europe PMC] [Abstract]

"Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer."
Oncogene 23:3487-3494(2004) [PubMed] [Europe PMC] [Abstract]

"MafA transcription factor is phosphorylated by p38 MAP kinase."
FEBS Lett. 579:3547-3554(2005) [PubMed] [Europe PMC] [Abstract]

"A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin."
Blood 110:4047-4054(2007) [PubMed] [Europe PMC] [Abstract]

"Cell context reveals a dual role for Maf in oncogenesis."
Oncogene 25:1299-1310(2006) [PubMed] [Europe PMC] [Abstract]

"CD13/APN transcription is regulated by the proto-oncogene c-Maf via an atypical response element."
Gene 403:178-187(2007) [PubMed] [Europe PMC] [Abstract]

"GSK-3-mediated phosphorylation enhances Maf-transforming activity."
Mol. Cell 28:584-597(2007) [PubMed] [Europe PMC] [Abstract]

"A new MAFia in cancer."
Nat. Rev. Cancer 8:683-693(2008) [PubMed] [Europe PMC] [Abstract]

"Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma."
Hum. Mol. Genet. 11:33-42(2002) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant 'cerulean cataract' in an Indian family."
Am. J. Med. Genet. A 140:558-566(2006) [PubMed] [Europe PMC] [Abstract]