Lymphocyte Adaptor Protein (Lnk)

SH2B3; IDDM20; SH2B Adaptor Protein 3; Lymphocyte-specific adapter protein Lnk; Signal transduction protein Lnk

SPN	P010
HGNC	29605
MGI	893598
PubMed	20038804
RGD	68411
UniProt	Q9UQQ2
Wiki	SH2B3

SH2B3 is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.

Sequence analysis predicted that the 575-amino acid LNK protein contains an N-terminal proline-rich region, a pleckstrin homology (PH) domain, and an Src homology 2 (SH2) domain; the PH and SH2 domains are similar to those of the APS protein. Northern blot analysis detected low expression of a 6.8-kb LNK transcript in various lymphoid cell lines. Confocal fluorescence microscopy showed that the majority of LNK is located in the juxtanuclear region with some found near the plasma membrane.

Reference

"Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation."
J. Immunol. 164:5199-5206(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes."
Nat. Genet. 39:857-864(2007) [PubMed] [Europe PMC] [Abstract]

"Newly identified genetic risk variants for celiac disease related to the immune response."
Nat. Genet. 40:395-402(2008) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]