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Klotho (KL)
Klotho (KL)
Klotho is a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al. The name of the gene comes from Klotho or Clotho, one of the Moirae, or Fates, in Greek mythology.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O987Hu01
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
MO987Hu21
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
PO987Hu01
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
KEO987Hu
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
KCO987Hu
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
O987Ra01
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
MO987Ra21
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
PO987Ra01
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
KEO987Ra
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Klotho (KL) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Klotho (KL) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Klotho (KL) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Klotho (KL) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Klotho (KL) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Klotho (KL) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Klotho (KL) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Klotho (KL) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Klotho (KL) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Klotho (KL) CLIA assay for Antigen Detection
Reference
"Mutation of the mouse klotho gene leads to a syndrome resembling ageing." Nature 390:45-51(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein." Biochem. Biophys. Res. Commun. 242:626-630(1998) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys." Biochem. Biophys. Res. Commun. 267:597-602(2000) [PubMed ] [Europe PMC ] [Abstract ]
"Molecular cloning and expression of a novel klotho-related protein." J. Mol. Med. 78:389-394(2000) [PubMed ] [Europe PMC ] [Abstract ]
"Severely reduced production of klotho in human chronic renal failure kidney." Biochem. Biophys. Res. Commun. 280:1015-1020(2001) [PubMed ] [Europe PMC ] [Abstract ]
"Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane." FEBS Lett. 565:143-147(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Association of human aging with a functional variant of klotho." Proc. Natl. Acad. Sci. U.S.A. 99:856-861(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity." Circ. Res. 96:412-418(2005) [PubMed ] [Europe PMC ] [Abstract ]
"The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed ] [Europe PMC ] [Abstract ]
"A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis." J. Clin. Invest. 117:2684-2691(2007) [PubMed ] [Europe PMC ] [Abstract ]
