Inter Alpha-Globulin Inhibitor H1 (ITIH1)

H1P; IATIH; ITIH; IGHEP1; Serum-derived hyaluronan-associated protein; Inter-alpha-trypsin inhibitor complex component III

SPN	O965
HGNC	6166
MGI	96618
PubMed	10100603
RGD	1306099
UniProt	P19827
Wiki	ITIH1

Salier et al. (1987) characterized cDNAs for the H chain of IATI. Diarra-Mehrpour et al. (1989) showed that human poly(A)-rich RNAs hybrid-selected with various heavy-chain-encoding cDNA clones translate 3 different heavy chains, designated H1 (M(r) 92,000), H2 (ITIH2), and H3 (ITIH3). Two previously characterized heavy-chain cDNA clones were found to correspond to the H1 and H2 chains. The deduced amino acid sequence of the H3 chain was found to be highly similar to those of the H1 (54%) and H2 (44%) chains. Diarra-Mehrpour et al. (1992) used a PCR-based cloning approach and cDNA library screening to isolate the full-length cDNA H1. The results of Northern blot analysis by Bost et al. (1993) indicated that the 2.9-kb ITIH1 mRNA is expressed only in liver.

Reference

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Biochim. Biophys. Acta 1132:114-118(1992) [PubMed] [Europe PMC] [Abstract]

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"Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related."
Eur. J. Biochem. 181:571-576(1989) [PubMed] [Europe PMC] [Abstract]

"A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor."
J. Biol. Chem. 268:26725-26730(1993) [PubMed] [Europe PMC] [Abstract]

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"cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins."
Biol. Chem. Hoppe-Seyler 368:963-970(1987) [PubMed] [Europe PMC] [Abstract]

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Eur. J. Biochem. 221:881-888(1994) [PubMed] [Europe PMC] [Abstract]

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