Interferon Regulatory Factor 9 (IRF9)

ISGF3G; ISGF3; p48; Interferon-Stimulated Transcription Factor 3,Gamma 48kDa; IFN-alpha-responsive transcription factor subunit; Interferon-stimulated gene factor 3 gamma

SPN	O964
HGNC	6131
MGI	107587
PubMed	22902549
RGD	1308766
UniProt	Q00978
Wiki	IRF9

ISGF3 is an interferon-dependent, positive-acting transcription factor that is cytoplasmically activated, possibly through direct interaction with the interferon receptor.

The attachment of interferon-alpha (IFNA) to a specific cell surface receptor activates the transcription of a limited set of genes termed the IFN-stimulated genes. Supporting the notion that the proteins in ISGF3 are links between an occupied receptor and a limited set of genes were the observations that the proteins preexist in untreated cells, are promptly activated in an IFN-alpha-dependent fashion in the cell cytoplasm, and are subsequently translocated to the nucleus. Four proteins of 48 (ISGF3G), 84, 91, and 113 kD (STAT2) make up the ISGF3 complex.

Reference

"Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins."
Mol. Cell. Biol. 12:3315-3324(1992) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation."
J. Interferon Cytokine Res. 22:103-109(2002) [PubMed] [Europe PMC] [Abstract]

"Viral inhibition of interferon signal transduction."
Intervirology 42:325-330(1999) [PubMed] [Europe PMC] [Abstract]