Iron Responsive Element Binding Protein 2 (IREB2)

IRP2; Iron regulatory protein 2

SPN	O955
HGNC	6115
MGI	1928268
PubMed	22461431
RGD	621539
UniProt	P48200

The second IREBP, represented by 'clone 10.1,' contained an inserted stretch of 73 amino acids between amino acids 37 and 38 of IREB1; the IREB2 gene product lacked a region homologous to the sequences between amino acids 436 and 470 of IREB1.Human IRP2 is 57% identical to human IRP1. IRP2 has a molecular mass of 105 kD, which is slightly larger than that of IRP1 due to a 73-amino acid insertion. IRP2-null cells misregulated iron metabolism when cultured in 3 to 6% oxygen, which is comparable to physiologic tissue concentrations, but not in 21% oxygen, a concentration that activated IRP1 and allowed it to substitute for IRP2. Thus, IRP2 dominates regulation of mammalian iron homeostasis because it alone registers iron concentrations and modulates its RNA-binding activity at physiologic oxygen tensions.

Reference

"Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation."
J. Biol. Chem. 269:30904-30910(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of the cDNA encoding an RNA regulatory protein -- the human iron-responsive element-binding protein."
Proc. Natl. Acad. Sci. U.S.A. 87:7958-7962(1990) [PubMed] [Europe PMC] [Abstract]

"Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels."
J. Biol. Chem. 270:16529-16535(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2."
Nat. Cell Biol. 5:336-340(2003) [PubMed] [Europe PMC] [Abstract]

"Control of iron homeostasis by an iron-regulated ubiquitin ligase."
Science 326:718-721(2009) [PubMed] [Europe PMC] [Abstract]

"An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis."
Science 326:722-726(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]