Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1)

XLKD1; CRSBP-1; HAR; Extracellular Link Domain Containing 1; Hyaluronic acid receptor; Cell surface retention sequence-binding protein 1

SPN	O900
HGNC	14687
MGI	2136348
PubMed	11377291
RGD	1310864
UniProt	Q9Y5Y7
Wiki	LYVE1

LYVE1 encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes.

Sequence analysis predicted that the 322-amino acid type I integral membrane glycoprotein is 41% similar to CD44. LYVE1 contains a leader peptide; a 212-residue extracellular domain with 7 cysteine residues, a serine/threonine-rich region, and 2 potential N-linked glycosylation sites; a 21-amino acid transmembrane domain; and a 63-residue cytoplasmic tail.

Reference

"LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific receptor for hyaluronan."
J. Cell Biol. 144:789-801(1999) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]