Histidine Triad Nucleotide Binding Protein 1 (HINT1)

HINT; PKCI1; PRKCNH1; Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1

SPN	O840
HGNC	4912
MGI	1321133
PubMed	22961002
RGD	1593411
UniProt	P49773
Wiki	HINT1

PRKCNH1 is a member of a family of small proteins found in several species that inhibit PKC activity in the presence of the 14-3-3 proteins.the PKCI1 protein interacts with the regulatory domain of PKC-beta in the yeast 2-hybrid system. In the same system, PKCI1 also interacts with the ataxia-telangiectasia group D protein, which is mutant in ataxia-telangiectasia . PKCI1 was a potent inhibitor of PKC.

The authors commented that the protein is a member of the HIT family of proteins; the term HIT refers to the histidine triad near the C terminus in this family (i.e., his110, his112, and his114 in the human PKCI1 sequence). They noted that FHIT, a putative tumor suppressor gene, is a PKCI1 homolog.

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins."
Proc. Natl. Acad. Sci. U.S.A. 93:5357-5362(1996) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 280:15356-15361(2005) [PubMed] [Europe PMC] [Abstract]

"The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription."
J. Cell Sci. 118:3117-3129(2005) [PubMed] [Europe PMC] [Abstract]

"The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity."
J. Biol. Chem. 281:27356-27366(2006) [PubMed] [Europe PMC] [Abstract]

"Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate."
J. Biol. Chem. 282:15137-15147(2007) [PubMed] [Europe PMC] [Abstract]

"Histidine triad nucleotide-binding protein 1 up-regulates cellular levels of p27KIP1 by targeting ScfSKP2 ubiquitin ligase and Src."
J. Biol. Chem. 284:5265-5276(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells."
Cell Cycle 11:2206-2215(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure-based analysis of catalysis and substrate definition in the HIT protein family."
Science 278:286-290(1997) [PubMed] [Europe PMC] [Abstract]

"A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution."
Acta Crystallogr. F 68:883-888(2012) [PubMed] [Europe PMC] [Abstract]

"Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor."
J. Phys. Chem. B 116:6798-6805(2012) [PubMed] [Europe PMC] [Abstract]

"Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia."
Nat. Genet. 44:1080-1083(2012) [PubMed] [Europe PMC] [Abstract]