Hemogen (HEMGN)

EDAG; EDAG-1; NDR; Erythroid differentiation-associated gene protein; Hemopoietic gene protein; Negative differentiation regulator protein

SPN	O831
HGNC	17509
MGI	2136910
PubMed	14648837
RGD	621569
UniProt	Q9BXL5
Wiki	HEMGN

The deduced mouse and human proteins contain 503 and 484 amino acids, respectively, and share 43% identity. A coiled-coil region and bipartite nuclear localization signal are conserved in the N termini of both proteins. Northern blot analysis detected a major 2.4-kb transcript and a minor 1.8-kb transcript in adult human bone marrow and fetal liver. HEMGN high expression in untreated and mitogen-treated K562 cells, adult bone marrow, and CD34-positive progenitor cells. Lower expression was detected in a child thymus and in a histiocyte lymphoma cell line, but no expression was detected in cultured T cells, monocytes, and nonhematopoietic cell lines examined. Hemgn was expressed in developing hepatic primordia at day 10.5 and, from day 11.5, it was expressed exclusively in fetal liver.

Reference

"Hemogen is a novel nuclear factor specifically expressed in mouse hematopoietic development and its human homologue EDAG maps to chromosome 9q22, a region containing breakpoints of hematological neoplasms."
Mech. Dev. 104:105-111(2001) [PubMed] [Europe PMC] [Abstract]

"Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis."
Dev. Dyn. 228:606-616(2003) [PubMed] [Europe PMC] [Abstract]

"EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B."
Cell Death Differ. 11:1299-1308(2004) [PubMed] [Europe PMC] [Abstract]

"Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells."
J. Biomed. Sci. 11:104-116(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"High expression of EDAG and its significance in AML."
Leukemia 19:1499-1502(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Scanning of novel cancer/testis proteins by human testis proteomic analysis."
Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]