Hepatitis A Virus Cellular Receptor 2 (HAVCR2)
KIM-3; TIM3; TIMD3; Tim-3; T-cell membrane protein 3; T-cell immunoglobulin mucin receptor 3; T-cell immunoglobulin and mucin domain-containing protein 3
Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.The deduced 301-amino acid type I membrane protein, 63% identical overall and 77% identical in the cytoplasmic domain, has an Ig variable-like domain, a mucin-like domain consisting of 31% serine and threonine residues, and a cytoplasmic domain with a tyrosine phosphorylation motif.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Hu01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Hu01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Hu01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Hu01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Hu01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Mu01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Mu01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Mu01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Mu01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Mu01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Ra01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Ra01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Ra01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Ra01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Ra01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Ca01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Ca01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Ca01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Ca01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Ca01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Po01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Po01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Po01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Po01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Po01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Bo01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Bo01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Bo01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Bo01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Bo01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Rb01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Rb01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Rb01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Rb01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Rb01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO818Mo01 | Recombinant Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO818Mo01 | Monoclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IP. |
| PAO818Mo01 | Polyclonal Antibody to Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO818Mo01 | CLIA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | CLIA assay for Antigen Detection |
| ELO818Mo01 | ELISA Kit for Hepatitis A Virus Cellular Receptor 2 (HAVCR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."
Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance."
Nat. Immunol. 4:1093-1101(2003) [PubMed] [Europe PMC] [Abstract]
"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."
Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]
"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]