Like Glycosyltransferase (LARGE)
Glycosyltransferase-like protein LARGE1; Acetylglucosaminyltransferase-like 1A
LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains.
It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.LARGE protein contains an N-terminal transmembrane domain, a coiled-coil domain, and 2 catalytic domains.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | O812Hu01 | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| PO812Hu01 | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Like Glycosyltransferase (LARGE) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Like Glycosyltransferase (LARGE) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Like Glycosyltransferase (LARGE) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Like Glycosyltransferase (LARGE) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Like Glycosyltransferase (LARGE) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Like Glycosyltransferase (LARGE) | CLIA assay for Antigen Detection |
Reference
"The human LARGE gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family."
Proc. Natl. Acad. Sci. U.S.A. 96:598-603(1999) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE."
Biochem. Biophys. Res. Commun. 329:1162-1171(2005) [PubMed] [Europe PMC] [Abstract]
"Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies."
Glycobiology 15:912-923(2005) [PubMed] [Europe PMC] [Abstract]
"Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy."
Hum. Mol. Genet. 14:657-665(2005) [PubMed] [Europe PMC] [Abstract]
"Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase."
Proc. Natl. Acad. Sci. U.S.A. 106:12109-12114(2009) [PubMed] [Europe PMC] [Abstract]
"Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection."
Proc. Natl. Acad. Sci. U.S.A. 108:17426-17431(2011) [PubMed] [Europe PMC] [Abstract]
"Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE."
Science 335:93-96(2012) [PubMed] [Europe PMC] [Abstract]
"The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated alpha-dystroglycan functional glycosylation."
Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]
"B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of alpha-dystroglycan."
Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]
"Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues."
J. Biol. Chem. 289:28138-28148(2014) [PubMed] [Europe PMC] [Abstract]
"Mutations in the human LARGE gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan."
Hum. Mol. Genet. 12:2853-2861(2003) [PubMed] [Europe PMC] [Abstract]
"Brain involvement in muscular dystrophies with defective dystroglycan glycosylation."
Ann. Neurol. 64:573-582(2008) [PubMed] [Europe PMC] [Abstract]
"Congenital muscular dystrophies with defective glycosylation of dystroglycan: a population study."
Neurology 72:1802-1809(2009) [PubMed] [Europe PMC] [Abstract]