Glycosylphosphatidylinositol Specific Phospholipase D1 (GPLD1)

GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D

SPN	O779
HGNC	4459
MGI	106604
PubMed	11072085
RGD	631371
UniProt	P80108
Wiki	GPLD1

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.

The deduced amino acid sequence contains 4 regions of internal homology that are similar to the metal ion binding domains of integrin alpha subunits. Bovine PIGPLD does not exhibit phosphatidylcholine-specific PLD activity.

Reference

"Isolation and expression of two human glycosylphosphatidylinositol phospholipase D (GPI-PLD) cDNAs."
FASEB J. 6:A1922-A1922(1992)

"Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene."
Biochim. Biophys. Acta 1494:189-194(2000) [PubMed] [Europe PMC] [Abstract]

"Preliminary study of the gene structure of human glycosylphosphatidylinositol specific phospholipase D."
Hunan Yi Ke Da Xue Xue Bao 26:96-97(2001)

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphatidylinositol-glycan-specific phospholipase D is an amphiphilic glycoprotein that in serum is associated with high-density lipoproteins."
Eur. J. Biochem. 206:747-757(1992) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]