Golgi Glycoprotein 1 (GLG1)

CFR-1; ESL-1; MG160; Golgi Apparatus Protein 1; E-selectin ligand 1; Cysteine-rich fibroblast growth factor receptor

SPN	O727
HGNC	4316
MGI	104967
PubMed	15797922
RGD	69345
UniProt	Q92896
Wiki	GLG1

MG-160, originally isolated from rat brain, is a conserved membrane sialoglycoprotein residing in the medial cisternae of the Golgi apparatus of most cells . The full-length cDNA encodes a predicted 1,179-amino acid protein that has a signal peptide, a proline- and glutamine-rich region, a cysteine-rich domain containing 5 potential asparagine-linked glycosylation sites, a hydrophobic transmembrane domain, and a short carboxy-terminal tail. The proline- and glutamine-rich segment contains a polyglutamine stretch which is encoded by an uninterrupted exonic sequence of CAG-CAA repeats. Human GLG1 shows between 88% and 95% overall amino acid identity with rat Glg1, mouse Esl1, and chicken CRF. The authors detected 3 transcripts of 10, 5, and 3.8 kb in several human fetal and adult tissues by Northern blot analysis.

Reference

"Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus."
DNA Cell Biol. 15:1121-1128(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Immunocytochemical visualization of the Golgi apparatus in several species, including human, and tissues with an antiserum against MG-160, a sialoglycoprotein of rat Golgi apparatus."
J. Histochem. Cytochem. 38:957-963(1990) [PubMed] [Europe PMC] [Abstract]

"Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160."
Biochem. J. 324:427-434(1997) [PubMed] [Europe PMC] [Abstract]

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]