Gastrokine 2 (GKN2)

TFIZ1; BLOT; GDDR; VLTI465; Blottin; Down Regulated In Gastric Cancer; Trefoil factor interactions(z) 1

SPN	O706
HGNC	24588
MGI	1913534
PubMed	17982272
RGD	1311934
UniProt	Q86XP6

Gastrokine-2 (GKN2) is a secretory peptide of human gastric surface mucous cells (SMCs). It forms disulfide-linked heterodimers with the trefoil factor family (TFF) peptide TFF1. Binding with TFF2 was also reported. Antral SMCs differ from those of the corpus by their TFF3 expression. GKN2 expression along the antral gland axis, to characterize the continuous regeneration of antral glands, and to investigate the interactions of GKN2 with TFF1, TFF2 and mucins.

Maturation of antral SMCs occurs stepwise via trans-differentiation of TFF3 expressing progenitor cells. The TFF1-GKN2 heterodimer and TFF2 differ haracteristically by their binding to gastric mucins. This points to different physiological functions of TFF1 and TFF2, the latter maybe acting as a “link peptide” for stabilization of the gastric mucus.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	O706Hu01	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	MO706Hu21	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	PO706Hu01	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	LO706Hu71	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	KEO706Hu	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCO706Hu	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	O706Mu01	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	PO706Mu01	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	LO706Mu71	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	O706Ra01	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	MO706Ra21	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	PO706Ra01	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	LO706Ra81	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	KEO706Ra	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCO706Ra	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Gastrokine 2 (GKN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Gastrokine 2 (GKN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Gastrokine 2 (GKN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Gastrokine 2 (GKN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Gastrokine 2 (GKN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Gastrokine 2 (GKN2)	CLIA assay for Antigen Detection

Reference

"Down-regulated full-length novel gene GDDR and its effect on gastric cancer."
Zhonghua Yi Xue Za Zhi 83:1166-1168(2003) [PubMed] [Europe PMC] [Abstract]

"Study on novel gene GDDR related to gastric cancer."
Zhonghua Wai Ke Za Zhi 43:10-13(2005) [PubMed] [Europe PMC] [Abstract]

"Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a Brichos domain-containing protein with homology to SP-C."
Biochemistry 44:7967-7975(2005) [PubMed] [Europe PMC] [Abstract]

"Identification of blottin: a novel gastric trefoil factor family-2 binding protein."
Proteomics 6:4235-4245(2006) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]