Follistatin Like Protein 3 (FSTL3)

FLRG; FSRP; Follistatin-Related Protein,Secreted Glycoprotein; Follistatin-related gene protein

SPN	O669
HGNC	3973
MGI	1890391
PubMed	23407452
RGD	621811
UniProt	O95633
Wiki	FSTL3

Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis.The FSTL3 cDNA, which they called FLRG (follistatin-related gene), encodes a deduced 263-amino acid protein that shares 85% amino acid identity with mouse Fstl3. It contains 2 cysteine-rich repeats that are closely related to the class 1-1 follistatin modules present in other follistatin family members. Northern blot analysis demonstrated expression of a 2.5-kb transcript in placenta, amniocytes, chorionic villosities, and bone marrow stromal cells, with weaker expression in fibroblasts, keratinocytes, and endothelial cells. A 1.3-kb transcript was also detected in some human tissues and was thought to result from use of an alternate polyadenylation site.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Hu01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Hu01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Hu01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Hu01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Hu01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Mu01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Mu01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Mu01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Mu01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Mu01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Ra01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Ra01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Ra01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Ra01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Ra01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Ca01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Ca01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Ca01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Ca01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Ca01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Po01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Po01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Po01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Po01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Po01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Bo01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Bo01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Bo01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Bo01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Bo01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Rb01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Rb01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Rb01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Rb01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Rb01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO669Mo01	Recombinant Follistatin Like Protein 3 (FSTL3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO669Mo01	Monoclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IP.
Antibodies	PAO669Mo01	Polyclonal Antibody to Follistatin Like Protein 3 (FSTL3)	WB; IHC; ICC; IF.
Assay Kits	CLO669Mo01	CLIA Kit for Follistatin Like Protein 3 (FSTL3)	CLIA assay for Antigen Detection
Assay Kits	ELO669Mo01	ELISA Kit for Follistatin Like Protein 3 (FSTL3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders."
Oncogene 16:2949-2954(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Human follistatin-related protein: a structural homologue of follistatin with nuclear localization."
Endocrinology 142:3426-3434(2001) [PubMed] [Europe PMC] [Abstract]

"Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function."
Oncogene 21:2227-2235(2002) [PubMed] [Europe PMC] [Abstract]

"Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG)."
Endocrinology 144:1671-1674(2003) [PubMed] [Europe PMC] [Abstract]

"Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells."
J. Clin. Endocrinol. Metab. 88:4432-4439(2003) [PubMed] [Europe PMC] [Abstract]

"FLRG, member of the follistatin family, a new player in hematopoiesis."
Mol. Cell. Endocrinol. 225:109-118(2004) [PubMed] [Europe PMC] [Abstract]

"FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."
Biol. Cell 97:577-588(2005) [PubMed] [Europe PMC] [Abstract]

"Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3."
Endocrinology 146:5052-5062(2005) [PubMed] [Europe PMC] [Abstract]

"A novel role for fibronectin type I domain in the regulation of human hematopoietic cell adhesiveness through binding to follistatin domains of FLRG and follistatin."
Exp. Cell Res. 312:434-442(2006) [PubMed] [Europe PMC] [Abstract]

"AF10-dependent transcription is enhanced by its interaction with FLRG."
Biol. Cell 99:563-571(2007) [PubMed] [Europe PMC] [Abstract]

"Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."
J. Med. Invest. 54:276-288(2007) [PubMed] [Europe PMC] [Abstract]

"The structure of FSTL3.activin A complex. Differential binding of N-terminal domains influences follistatin-type antagonist specificity."
J. Biol. Chem. 283:32831-32838(2008) [PubMed] [Europe PMC] [Abstract]

"Structure of myostatin.follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding."
J. Biol. Chem. 287:1043-1053(2012) [PubMed] [Europe PMC] [Abstract]