The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.
Structure-function analysis demonstrated that the major carboxy-terminal transactivation domains of Fos and FosB are dispensable and that Fosl1, which lacks transactivation domains, has the highest rescue activity. Moreover, a transgene expressing Fosl1 rescued the osteopetrosis of Fos mutant mice in vivo. The osteoclast differentiation factor Rankl induced transcription of Fosl1 in a Fos-dependent manner, thereby establishing a link between Rank signaling and the expression of Ap1 proteins in osteoclast differentiation.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Hu01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Hu01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Hu01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Hu01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Hu01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Mu01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Mu01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Mu01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Mu01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Mu01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Ra01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Ra01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Ra01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Ra01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Ra01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Ca01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Ca01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Ca01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Ca01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Ca01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Po01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Po01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Po01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Po01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Po01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Bo01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Bo01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Bo01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Bo01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Bo01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Rb01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Rb01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Rb01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Rb01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Rb01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
RPO664Mo01
Recombinant FOS Like Antigen 1 (FOSL1)
Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies
MAO664Mo01
Monoclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IP.
PAO664Mo01
Polyclonal Antibody to FOS Like Antigen 1 (FOSL1)
WB; IHC; ICC; IF.
Assay Kits
CLO664Mo01
CLIA Kit for FOS Like Antigen 1 (FOSL1)
CLIA assay for Antigen Detection
ELO664Mo01
ELISA Kit for FOS Like Antigen 1 (FOSL1)
Enzyme-linked immunosorbent assay for Antigen Detection
Reference
"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation." Oncogene 5:249-255(1990) [PubMed] [Europe PMC] [Abstract]
"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals." J. Virol. 67:7001-7007(1993) [PubMed] [Europe PMC] [Abstract]