Farnesyltransferase Beta (FNTb)

FPTB; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta

SPN	O663
HGNC	3785
MGI	1861305
PubMed	18477117
RGD	620119
UniProt	P49356
Wiki	FNTB

Andres et al. (1993) localized the gene for the beta subunit of CAAX farnesyltransferase (FNTB) to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization. They found a related farnesyltransferase gene, FNTBL1, on chromosome 9.Long et al. (2002) presented a complete series of structures representing the major steps along the reaction coordinate of the enzyme protein farnesyltransferase. From these observations, Long et al. (2002) deduced the determinants of substrate specificity and an unusual mechanism in which product release requires binding of substrate, analogous to classically processive enzymes. A structural model for the transition state consistent with previous mechanistic studies was also constructed.

Reference

"Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases."
Biochemistry 32:5167-5176(1993) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences."
Genomics 18:105-112(1993) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics."
Proc. Natl. Acad. Sci. U.S.A. 98:12948-12953(2001) [PubMed] [Europe PMC] [Abstract]

"3-aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency."
J. Med. Chem. 45:2388-2409(2002) [PubMed] [Europe PMC] [Abstract]

"Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents."
J. Med. Chem. 46:2973-2984(2003) [PubMed] [Europe PMC] [Abstract]

"Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity."
J. Mol. Biol. 343:417-433(2004) [PubMed] [Europe PMC] [Abstract]

"Conversion of protein farnesyltransferase to a geranylgeranyltransferase."
Biochemistry 45:9746-9755(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase."
Chem. Biol. 16:181-192(2009) [PubMed] [Europe PMC] [Abstract]