Eosinophil Peroxidase (EPX)

EPO; EPP; EPX-PEN; EPER

SPN	O611
HGNC	3423
MGI	107569
PubMed	22750539
RGD	1311882
UniProt	P11678
Wiki	EPX

Eosinophil peroxidase is a haloperoxidase enzymeencoded by the EPX gene. The enzyme is a heterodimeric 71-77 kD peroxidase consisting of a heavier glycosylated chain and a lighter nonglycosylated chain. In the presence of H₂O₂ formed by the eosinophil, and either chloride or bromide ions, eosinophil peroxidase provides a potent mechanism by which eosinophils kill multicellular parasites (such as, for example, the nematode worms involved in filariasis); and also certain bacteria (such as tuberculosis bacteria). Eosinophil peroxidase is a haloperoxidase that preferentially uses bromide over chloride for this purpose, generating hypobromite (hypobromous acid). The enzyme is also capable of oxidizing thiocyanate (SCN-) and uses it as a co-substrate, with optimal concentrations occurring at about normal plasma levels.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Hu01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Hu01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Hu01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Hu01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Hu01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Mu01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Mu01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Mu01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Mu01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Mu01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Ra01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Ra01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Ra01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Ra01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Ra01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Ca01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Ca01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Ca01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Ca01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Ca01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Po01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Po01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Po01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Po01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Po01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Bo01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Bo01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Bo01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Bo01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Bo01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Rb01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Rb01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Rb01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Rb01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Rb01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO611Mo01	Recombinant Eosinophil Peroxidase (EPX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO611Mo01	Monoclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IP.
Antibodies	PAO611Mo01	Polyclonal Antibody to Eosinophil Peroxidase (EPX)	WB; IHC; ICC; IF.
Assay Kits	CLO611Mo01	CLIA Kit for Eosinophil Peroxidase (EPX)	CLIA assay for Antigen Detection
Assay Kits	ELO611Mo01	ELISA Kit for Eosinophil Peroxidase (EPX)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of a chromosomal gene for human eosinophil peroxidase."
J. Biol. Chem. 264:16828-16836(1989) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the human eosinophil peroxidase. Evidence for the existence of a peroxidase multigene family."
J. Exp. Med. 169:1757-1769(1989) [PubMed] [Europe PMC] [Abstract]

"Biochemical evidence for heme linkage through esters with Asp-93 and Glu-241 in human eosinophil peroxidase. The ester with Asp-93 is only partially formed in vivo."
J. Biol. Chem. 274:16953-16958(1999) [PubMed] [Europe PMC] [Abstract]

"Human eosinophil peroxidase induces surface alteration, killing, and lysis of Mycobacterium tuberculosis."
Infect. Immun. 71:605-613(2003) [PubMed] [Europe PMC] [Abstract]

"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]

"Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect."
Proc. Natl. Acad. Sci. U.S.A. 91:12496-12500(1994) [PubMed] [Europe PMC] [Abstract]

"High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis."
J. Allergy Clin. Immunol. 112:1127-1131(2003) [PubMed] [Europe PMC] [Abstract]