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Regulator Of Calcineurin 1 (RCAN1)

ADAPT78; CSP1; DSC1; DSCR1; MCIP1; Down Syndrome Critical Region Gene 1; Calcipressin-1; Myocyte-enriched calcineurin-interacting protein 1

RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. The predicted 171-amino acid protein contains 2 proline-rich regions, a putative DNA-binding domain, and an acidic region. Northern blot analysis revealed that the 2.2-kb DSCR1 transcript is expressed at the highest levels in fetal brain and adult heart and at lower levels in various other tissues. An additional 2-kb mRNA was detected in fetal and adult liver.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits KEO525Hu ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Regulator Of Calcineurin 1 (RCAN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Regulator Of Calcineurin 1 (RCAN1) Bioactivity
Antibodies NONE Monoclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Regulator Of Calcineurin 1 (RCAN1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Regulator Of Calcineurin 1 (RCAN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Regulator Of Calcineurin 1 (RCAN1) CLIA assay for Antigen Detection

Reference

"A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart."
Hum. Mol. Genet. 4:1935-1944(1995) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene."
Genomics 44:358-361(1997) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life."
Biochem. J. 374:567-575(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways."
Hum. Mol. Genet. 9:1681-1690(2000) [PubMed] [Europe PMC] [Abstract]

"Raf-1 is a binding partner of DSCR1."
Arch. Biochem. Biophys. 439:121-128(2005) [PubMed] [Europe PMC] [Abstract]