Deleted In Malignant Brain Tumors 1 (DMBT1)

GP340; SAG; Muclin; Glycoprotein 340; Hensin; Salivary agglutinin; Surfactant pulmonary-associated D-binding protein

SPN	O498
HGNC	2926
MGI	106210
PubMed	9288095
RGD	61984
UniProt	Q9UGM3
Wiki	DMBT1

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Reference

"DMBT1, a new member of the SRCR superfamily on chromosome 10q25.3-q26.1 is deleted in malignant brain tumours."
Nat. Genet. 17:32-39(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D."
Proc. Natl. Acad. Sci. U.S.A. 96:10794-10799(1999) [PubMed] [Europe PMC] [Abstract]

"The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability."
Oncogene 18:6233-6240(1999) [PubMed] [Europe PMC] [Abstract]

"Expression of the DMBT1 gene is frequently suppressed in human lung cancer."
Jpn. J. Cancer Res. 90:903-908(1999) [PubMed] [Europe PMC] [Abstract]

"Deleted in malignant brain tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer."
Cancer Res. 61:8880-8886(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule."
J. Biol. Chem. 272:13743-13749(1997) [PubMed] [Europe PMC] [Abstract]

"Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner."
Am. J. Respir. Cell Mol. Biol. 20:759-768(1999) [PubMed] [Europe PMC] [Abstract]

"Lack of DMBT1 expression in oesophageal, gastric and colon cancers."
Br. J. Cancer 79:211-213(1999) [PubMed] [Europe PMC] [Abstract]

"DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer."
Cancer Res. 60:1704-1710(2000) [PubMed] [Europe PMC] [Abstract]

"Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340."
J. Biol. Chem. 275:39860-39866(2000) [PubMed] [Europe PMC] [Abstract]

"Bacteria binding by DMBT1/SAG/gp-340 is confined to the VEVLXXXXW motif in its scavenger receptor cysteine-rich domains."
J. Biol. Chem. 279:47699-47703(2004) [PubMed] [Europe PMC] [Abstract]

"The N-terminal SRCR-SID domain of gp-340 interacts with HIV type 1 gp120 sequences and inhibits viral infection."
AIDS Res. Hum. Retroviruses 22:508-515(2006) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease."
Gastroenterology 133:1499-1509(2007) [PubMed] [Europe PMC] [Abstract]

"Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion."
J. Immunol. 178:8203-8211(2007) [PubMed] [Europe PMC] [Abstract]

"gp340 expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission."
J. Immunol. 179:3126-3132(2007) [PubMed] [Europe PMC] [Abstract]

"A common binding motif for various bacteria of the bacteria-binding peptide SRCRP2 of DMBT1/gp-340/salivary agglutinin."
Biol. Chem. 389:1193-1200(2008) [PubMed] [Europe PMC] [Abstract]

"DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands."
Eur. J. Immunol. 39:833-842(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer."
Genes Chromosomes Cancer 35:242-255(2002) [PubMed] [Europe PMC] [Abstract]

"Rare mutations of the DMBT1 gene in human astrocytic gliomas."
Oncogene 21:5956-5959(2002) [PubMed] [Europe PMC] [Abstract]