Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2)
ARAT; Acyl-CoA retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2
The deduced 387-amino acid human protein contains at least 1 transmembrane domain, 3 potential N-linked glycosylation sites, 6 potential phosphorylation sites, and a putative glycerol phospholipid domain found in acyltransferases. Northern blot analysis revealed expression of 2.4- and 1.8-kb DGAT2 transcripts. Highest expression was in liver and white adipose tissue, with lower levels in mammary gland, testis, and peripheral blood leukocytes. Functional analysis confirmed DGAT activity, which was dependent on the presence of fatty acyl-CoA and diacylglycerol, in the membranes of DGAT2-expressing cells. The authors found that DGAT2 functions in the presence of low levels of magnesium chloride, whereas DGAT1 functions best at higher levels of magnesium chloride.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Hu01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Hu01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Hu01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Hu01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Hu01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Mu01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Mu01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Mu01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Mu01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Mu01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Ra01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Ra01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Ra01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Ra01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Ra01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Ca01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Ca01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Ca01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Ca01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Ca01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Po01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Po01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Po01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Po01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Po01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Bo01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Bo01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Bo01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Bo01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Bo01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Rb01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Rb01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Rb01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Rb01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Rb01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO473Mo01 | Recombinant Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO473Mo01 | Monoclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IP. |
| PAO473Mo01 | Polyclonal Antibody to Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO473Mo01 | CLIA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | CLIA assay for Antigen Detection |
| ELO473Mo01 | ELISA Kit for Diacylglycerol-O-Acyltransferase Homolog 2 (DGAT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members."
J. Biol. Chem. 276:38870-38876(2001) [PubMed] [Europe PMC] [Abstract]
"A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice."
Biochem. Biophys. Res. Commun. 310:296-302(2003) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
"Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1."
Biochim. Biophys. Acta 1737:76-82(2005) [PubMed] [Europe PMC] [Abstract]