Dolichyl Diphosphooligosaccharide Protein Glycosyltransferase (DDOST)

AGE-R1; OK/SW-cl.45; OST; OST48; WBP1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Oligosaccharyl transferase 48 kDa

SPN	O466
HGNC	2728
MGI	1194508
PubMed	22305527
RGD	1308970
UniProt	P39656
Wiki	DDOST

DDOST encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.DDOST mRNA was expressed intensely in heart and pancreas, but at lower levels in brain. the gene encoding the human DDOST 48-kD subunit is organized into 11 exons spanning about 9 kb. By fluorescence in situ hybridization, they assigned the DDOST subunit gene to chromosome 1p36.1.

Reference

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation."
Am. J. Hum. Genet. 90:363-368(2012) [PubMed] [Europe PMC] [Abstract]