D-Aspartate Oxidase (DDO)

DASOX; DDO-1; DDO-2

SPN	O465
HGNC	2727
MGI	1925528
PubMed	9163533
RGD	1595123
UniProt	Q99489
Wiki	DDO

D-Aspartate Oxidaseis a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene.

The human DDO1 protein has 86.4% amino acid identity with bovine DDO. DDO1 produces a 37-kD protein that efficiently oxidizes D-aspartate and N-methyl-D-aspartate but not D-glutamate; DDO2 produces an insoluble protein whose functional role could not be determined.Indeed it is the existence of these variants that showed the autosomal inheritance and genetic separateness from D-amino acid oxidase.

Reference

"Structural and functional characterization of the human brain D-aspartate oxidase."
J. Biochem. 121:798-803(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]